AAV‑IKV retinal penetration
Outer retinal delivery from the vitreous, including photoreceptor and RPE transgene expression in preclinical studies.
Evidence base
Peer‑reviewed studies supporting retinal penetration, decorin biology, and cargo delivery.
The public research package addresses retinal AAV penetration, Nuc1-mediated cargo delivery, AAV‑IKV‑Decorin in wet AMD models, and AAV‑IKV‑Decorin in glaucoma models.
Research themes
Four experimentally defined themes.
The studies connect delivery technology to disease-relevant payloads and ocular compartments.
Nuc1 cargo delivery
A cell‑penetrating chaperone designed to assist delivery of proteins, antibodies, peptides, steroids, and viral vectors without chemical conjugation.
Wet AMD: CNV and fibrosis
AAV‑IKV‑Decorin delivery was studied in laser‑induced CNV with readouts for neovascularization, fibrosis, inflammation, and autophagy.
Glaucoma fibrosis biology
AAV‑IKV‑Decorin studies focus on TGFβ2‑driven trabecular meshwork fibrosis, elevated IOP, retinal ganglion cell degeneration, and non‑human primate observations.
Research package
Selected publications and manuscripts.
The following manuscripts provide the scientific basis for the publicly described platform and preclinical programs.
IOVS, 2024
Open PDFRetinal Penetrating Adeno‑Associated Virus
AAV‑IKV design and outer retinal delivery from an intravitreal route.
IOVS, 2024
Open PDFCell‑Penetrating Chaperone Nuc1 for Small‑ and Large‑Molecule Delivery Into Retinal Cells and Tissues
Nuc1 chaperone delivery of small and large cargo into retinal cells without chemical conjugation.
Experimental Eye Research, 2025
Open PDFIntravitreal AAV‑IKV Mediated Delivery of Decorin Inhibits CNV, Fibrosis, Inflammation and Elevates Autophagy
Wet AMD program rationale using AAV‑IKV‑Decorin in laser-induced CNV, including fibrotic and neovascular outcomes.
Scientific Reports, 2025
Open PDFAAV‑IKV Mediated Expression of Decorin Inhibits EMT and Fibrosis in a Murine Model of Glaucoma and AAV‑IKV Transduction in Non‑Human Primates
Glaucoma program rationale, anterior segment transduction, and non‑human primate observations.
Supplementary research
Open PDFProtein and Gene Editing Delivery Studies
Additional research material illustrating protein and gene editing cargo delivery in ocular models.
Preclinical research
Platform studies connected to disease models.
The current public evidence is preclinical. It supports continued evaluation of AAV‑IKV delivery, decorin payload biology, Nuc1 cargo delivery, and complement-targeted retinal programs.
Delivery validation
AAV‑IKV and Nuc1 address delivery bottlenecks in retinal and anterior segment tissues.
Program biology
Decorin is being studied in wet AMD and glaucoma models where fibrosis is a measurable disease feature.
Complement strategy
The undisclosed dry AMD program applies local complement modulation to geographic atrophy biology.